D. Wetzel

The pH-responsive SmrR-SmrT system modulates C. difficile antimicrobial resistance, spore formation, and toxin production

This study identifies SmrR and SmrT as pH-responsive genes in C. difficile that regulate sporulation, toxin production, and antimicrobial resistance.

The predicted acetoin dehydrogenase pathway represses sporulation of Clostridioides difficile

This study shows that acetoin and pH regulate sporulation in C. difficile through the aco pathway, with acetoin metabolism not supporting growth as a stationary phase energy source.

Three orphan histidine kinases inhibit Clostridioides difficile sporulation

This study identifies three phosphotransfer proteins that repress Clostridioides difficile sporulation by regulating Spo0A phosphorylation.

Novel virus-like particle vaccine encoding the circumsporozoite protein of Plasmodium falciparum is immunogenic and induces functional antibody responses

This paper describes a novel virus-like particle vaccine using duck hepatitis B virus surface antigen to display Plasmodium falciparum CSP, showing improved immunogenicity and functional antibody responses in mice.

Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence

This paper identifies a phase-variable signal transduction system in C. difficile that controls colony morphology, motility, and virulence, with implications for bacterial survival and pathogenesis.

The impact of pH on Clostridioides difficile sporulation and physiology

This study investigates how different pH conditions affect the physiology of two C. difficile strains, showing strain-dependent differences in sporulation, motility, and toxin production.

Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity

This study evaluates a novel virus-like particle platform for malaria vaccines, showing immunogenicity and transmission-blocking activity against Pfs230 and Pfs25 antigens.