Author

R. Vale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 2 Assay:proteomics· 2 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:rat· 1

Frequent Co-Authors

C. B. Carbone· 2 shared W. Huynh· 2 shared A. N. Parikh· 1 shared C. R. Liem· 1 shared E. Hui· 1 shared J. K. Chung· 1 shared J. S. Weissman· 1 shared J. T. Groves· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

C. B. Carbone

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Author profile →

5 papers

Recent·Most cited

Coupling between lipid miscibility and phosphotyrosine driven protein condensation at the membrane

J. K. Chung, W. Y. C. Huang, C. B. Carbone, L. M. Nocka, A. N. Parikh, R. Vale, J. T. Groves

The paper shows that LAT protein condensation on membrane surfaces drives lipid phase separation, which in turn localizes K-Ras into the condensate, controlled by tyrosine phosphorylation.

bioRxiv · Jul 22, 2020 · PreprintBiophysics

High-content Imaging-based Pooled CRISPR Screens in Mammalian Cells

X. Yan, N. Stuurman, S. A. Ribeiro, M. E. Tanenbaum, M. A. Horlbeck, C. R. Liem, M. Jost, J. S. Weissman, R. Vale

The paper develops an imaging-based CRISPR screening method called optical enrichment to identify genes affecting nuclear size, identifying 14 hits from 6092 sgRNAs.

bioRxiv · Jun 30, 2020Cell Biology

A new calcium-activated dynein adaptor protein, CRACR2a, regulates clathrin-independent endocytic traffic in T cells

Y. Wang, W. Huynh, T. Skokan, R. Vale

bioRxiv · Jun 22, 2018Cell Biology

Disease-Associated Mutations In Human BICD2 Hyperactivate Motility Of Dynein-Dynactin

W. Huynh, R. Vale

This study shows that disease-associated BICD2 mutations enhance DDB motility, leading to impaired neurite growth and suggesting a link to spinal muscular atrophy.

bioRxiv · Sep 4, 2017Biochemistry

In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase

C. B. Carbone, N. Kern, R. A. Fernandes, E. Hui, X. Su, K. C. Garcia, R. Vale

This paper demonstrates that TCR-pMHC and PD-1-PD-L1 interactions can exclude CD45 from membrane interfaces, creating spatial organization that may regulate T cell signaling.

bioRxiv · Jun 7, 2017Immunology