Cancer BiologybioRxivPreprint
A non-canonical function of LDHB promotes SLC7A11-mediated glutathione metabolism and protects against glutaminolysis-dependent ferroptosis in KRAS-driven lung cancer
L. Zhao, H. Deng, J. Zhang…·R.-W. Peng
This study identifies a non-canonical role of LDHB in protecting KRAS-driven lung cancer from ferroptosis by promoting SLC7A11-mediated glutathione metabolism.
DOI 10.1101/2023.02.12.525859