L. Xing

Post-translational regulation of Platelet-derived growth factor receptor β is critical for fracture repair in aged mice

This study identifies PDGFRβ as a target of proteasome inhibitors in aged mice, showing that its degradation impairs fracture repair and that combined PDGF-BB and proteasome inhibitor treatment improves repair.

Senescent cells impair fracture repair through elevating ubiquitin-proteasome system activity in aged mice.

This study shows senescent cells impair fracture repair in aged mice by increasing ubiquitination of PDGFRβ via TGFβ, suggesting a new therapeutic target.

Longer mandible or nose? Co-evolution of feeding organs in early elephantiforms

This study investigates the co-evolution of feeding organs in early elephantiforms, finding that feeding function shifted from the mandible to the trunk, enabling proboscideans to expand into new ecological niches.

Artificial Intelligence Helps to Predict Recurrence and Mortality for Prostate Cancer using Histology Images

This study develops an AI system to predict prostate cancer recurrence using histology images, showing it outperforms existing grading systems in risk categorization.

Multi-omics Analysis Identifies IgG2b Class-Switching with ALCAM-CD6 Co-Stimulation in Lymph Nodes During Advanced Inflammatory-Erosive Arthritis

The paper identifies ALCAM-CD6 co-stimulation as a pathway promoting IgG2b class-switching in lymph nodes during advanced inflammatory arthritis using spatial and single-cell transcriptomics.

Root twisting drives halotropism via stress-induced microtubule reorientation

This study identifies the molecular mechanism of root halotropism in Arabidopsis, showing that ABA-mediated microtubule reorientation drives anisotropic cell expansion and root twisting in response to salt stress.

SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion

This study shows SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion by altering its structure and function.

The Siberian wild apple, Malus baccata (L.) Borkh., is an additional contributor to the genomes of cultivated European and Chinese apples

This study shows that Malus baccata contributes to the genomes of cultivated European and Chinese apples through gene flow, alongside Malus sylvestris and Malus sieversii.

The ataxia protein sacsin is required for integrin trafficking and synaptic organization

This study identifies sacsin's role in integrin trafficking and synaptic organization, showing its deficiency causes cellular phenotypes in ARSACS.

MiRNA-223 Inhibits MouseGallstone Formation by Targeting Key Transporters in Hepatobiliary Cholesterol Secretion Pathway

This study shows that miRNA-223 inhibits gallstone formation in mice by targeting ABCG5 and ABCG8, key transporters in the bile cholesterol secretion pathway.

Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors

The paper identifies three structurally diverse compounds as inhibitors of the SARS-CoV-2 3CL protease and provides structural insights for inhibitor design.

Reply to Li et al. "Is Oculudentavis a bird or even archosaur?"

The paper responds to a claim that Oculudentavis khaungraae is a squamate, arguing that the evidence is inconclusive and the specimen remains enigmatic.