Author

C. Dillen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 7 Research Focus:drug response / drug discovery· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

M. Frieman· 6 shared M. E. McGrath· 4 shared D. J. Dowling· 3 shared E. Nanishi· 3 shared H. L. Hammond· 3 shared H.-S. Seo· 3 shared L. Baracco· 3 shared M. B. Frieman· 3 shared

Activity by Year

2021-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Curved chords = mutual co-authorship

6 shared papersMicrobiology

M. Frieman

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression

M. Frieman, M. E. McGrath, Y. Xue, L. Taylor, C. Dillen, J. Ardanuy, N. Gonzalez-Juarbe, L. Baracco, R. Kim, R. Hart, N. Assad-Garcia, S. Vashee

This study shows that SARS-CoV-2 ORF8 protein modulates lung inflammation and disease severity in mice by affecting macrophage infiltration and function.

bioRxiv · Sep 8, 2023Microbiology

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.

T. R. O'Meara, E. Nanishi, M. E. McGrath, S. Barman, D. Dong, C. Dillen, M. Menon, H.-S. Seo, S. Dhe-Paganon, R. K. Ernst, O. Levy, M. B. Frieman, D. J. Dowling

bioRxiv · Dec 7, 2022Immunology

Diet Induced Obesity and Diabetes Enhance Mortality and Reduces Vaccine Efficacy for SARS-CoV-2

R. Johnson, J. Ardunay, H. Hammond, J. Logue, L. Jackson, L. Baracco, M. McGrath, C. Dillen, N. Patel, G. Smith, M. Frieman

This study shows that obesity and diabetes increase SARS-CoV-2 mortality and reduce vaccine efficacy in mice, with neutrophil depletion improving outcomes.

bioRxiv · Oct 15, 2022Microbiology

SARS-CoV-2 Variant Spike and accessory gene mutations alter pathogenesis

M. McGrath, Y. Xue, C. Dillen, L. Oldfield, N. Assad-Garcia, J. Zaveri, N. Singh, L. Baracco, L. Taylor, S. Vashee, M. Frieman

This study investigates how non-Spike mutations in SARS-CoV-2 variants affect pathogenesis and transmission, revealing that accessory gene mutations can lead to attenuating phenotypes.

bioRxiv · May 31, 2022Microbiology

Phage-like particle vaccines are highly immunogenic and protect against pathogenic coronavirus infection and disease

B. J. Davenport, A. Catala, S. M. Weston, R. M. Johnson, J. Ardunay, H. L. Hammond, C. Dillen, M. B. Frieman, C. E. Catalano, T. E. Morrison

This paper develops a phage-like particle vaccine platform that is immunogenic and protects against SARS-CoV-2 and MERS-CoV infection and disease.

bioRxiv · Nov 8, 2021Immunology

An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice

F. Borriello, E. Nanishi, H.-S. Seo, T. R. OMeara, M. E. McGrath, Y. Saito, R. E. Haupt, J. Chen, J. Diray-Arce, K. Song, A. Z. Xu, T. M. Caradonna, J. Feldman, B. M. Hauser, A. G. Schmidt, , O. Levy

This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.

bioRxiv · Sep 9, 2021 · PreprintImmunology

Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection

D. Schultz, R. Johnson, K. Ayyanathan, J. Miller, K. Whig, B. Kamalia, M. Dittmar, S. Weston, H. Hammond, C. Dillen, L. Castellana, J. S. Lee, M. Li, E. M. Lee, S. Constant, , S. Cherry

The paper screens 18,000 drugs for antiviral activity against SARS-CoV-2, identifies synergistic combinations of pyrimidine biosynthesis inhibitors and nucleoside analogs, and validates their efficacy in vitro and in vivo.

bioRxiv · Jun 24, 2021 · PreprintMicrobiology

Immunogenicity and In vivo protection of a variant nanoparticle vaccine that confers broad protection against emerging SARS-CoV-2 variants

J. Logue, R. Johnson, N. Patel, B. Zhou, S. Maciejewski, H. Zhou, A. Portnoff, J.-H. Tian, M. McGrath, R. Haupt, S. Weston, H. Hammod, M. Guebre-Xabier, C. Dillen, J. Plested, , M. Frieman

This study evaluates a nanoparticle vaccine against SARS-CoV-2 variants, showing it induces strong immune responses and protection in mice and baboons against multiple variants.

bioRxiv · Jun 8, 2021 · PreprintImmunology

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

E. Nanishi, F. Borriello, T. R. O'Meara, M. E. McGrath, Y. Saito, R. E. Haupt, H.-S. Seo, S. D. van Haren, B. Brook, J. Chen, J. Diray-Arce, S. Doss-Gollin, M. De Leon, K. Chew, M. Menon, , D. J. Dowling

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

bioRxiv · May 20, 2021Immunology