Author

S. D. Shelton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

P. Mishra· 3 shared D. G. McFadden· 2 shared R. J. DeBerardinis· 2 shared S. House· 2 shared X. Wang· 2 shared Z. Chen· 2 shared A. Frank· 1 shared A. R. Frank· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCancer Biology

P. Mishra

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivSep 1, 2023

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis

S. D. Shelton, S. House, V. Ramesh…·P. Mishra

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.

DOI 10.1126/sciadv.adk8801

𝕏 PostBluesky

Cancer BiologybioRxivAug 16, 2022

Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid

A. R. Frank, V. Li, S. D. Shelton…·D. G. McFadden

This study shows that mitochondrial complex I defects in thyroid cancer drive reliance on aerobic fermentation, which can be targeted with lactate dehydrogenase inhibitors.

DOI 10.1158/2159-8290.cd-22-0982

humanbulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivJul 15, 2021

Differential requirements for mitochondrial electron transport chain components in the adult murine liver

N. P. Lesner, X. Wang, Z. Chen…·P. Mishra

This study investigates the tissue-specific roles of mitochondrial complex I and IV in adult mouse liver, finding that complex I loss is tolerated while complex IV dysfunction causes metabolic and functional impairments.

DOI 10.7554/elife.80919

mousemetabolomics

𝕏 PostBluesky