S. Golfier

Novel YAP1/TAZ pathway inhibitors identified through phenotypic screening with potent anti-tumor activity via blockade of GGTase-I / Rho-GTPase signaling

Spindle scaling is governed by cell boundary regulation of microtubule nucleation

The paper shows that microtubule nucleation, not polymerization, governs spindle scaling across all cell sizes by regulating nucleation inhibitor partitioning to the cell membrane.

Surface condensation of a pioneer transcription factor on DNA

This study uses optical tweezers to observe Klf4 condensation on DNA, showing surface-mediated microphases that reconcile phase separation with nuclear organization.

Force generation by protein-DNA co-condensation

The paper shows DNA condensation mediated by transcription factors generates forces that bring distant DNA regions together, suggesting a physical mechanism for chromatin organization.

Top-down engineering of complex communities by directed evolution

This study develops a modeling framework to explore directed evolution strategies for engineering complex microbial communities, identifying effective methods to enhance their stability and functionality.

Cohesin and condensin extrude loops in a cell-cycle dependent manner

This study shows that cohesin and condensin extrude distinct types of loops in interphase and metaphase, respectively, revealing cell-cycle dependent loop extrusion dynamics.