Constitutive Androstane Receptor and Hepatitis B Virus X Protein Cooperatively Induce β-catenin-Activated Liver Tumors
J. Scott, S. Liu, K. Klatt, Z. Sun, Q. Guo, S. Grimm, C. Coarfa, B. Dong, D. D. Moore
This study shows that activating CAR with HBx in mice leads to liver tumors with strong β-catenin activation, mirroring human HBV-related HCC.
bioRxiv · Aug 8, 2020 · PreprintCancer Biology