Author

S. Vaidyanathan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

A. A. Salahudeen· 2 shared C. J. Kuo· 2 shared C. M. Lee· 2 shared D. T. Bravo· 2 shared G. Bao· 2 shared J. J. Wine· 2 shared J. V. Nayak· 2 shared T. J. Desai· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

A. A. Salahudeen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Prioritizing landscapes to reconcile biodiversity conservation, ecosystem services, and human well-being in India

A. Srivathsa, D. Vasudev, T. Nair, S. Chakrabarti, P. Chanchani, R. DeFries, A. Deomurari, S. Dutta, D. Ghose, V. Goswami, R. Nayak, A. Neelakantan, P. Thatte, S. Vaidyanathan, M. Verma, , U. Ramakrishnan

This study identifies priority landscapes in India for biodiversity conservation and ecosystem services that align with human well-being, finding that current protected areas cover only 15% of these regions.

bioRxiv · Aug 27, 2022 · PreprintEcology

Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis

M. A. Potts, S. Mizutani, Y. Deng, S. Vaidyanathan, K. Ting, G. Giner, S. Shruti, Y. Liao, S. Diepstraten, A. J. Kueh, M. Pal, G. Healey, L. Tai, Z. Wang, C. Koenig, , M. J. Herold

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

bioRxiv · Feb 16, 2022 · PreprintCancer Biology

Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus

S. Vaidyanathan, R. Baik, L. Chen, D. T. Bravo, C. J. Suarez, S. M. Abazari, A. A. Salahudeen, A. M. Dudek, C. A. Teran, T. H. Davis, C. M. Lee, G. Bao, S. H. Randell, S. E. Artandi, J. J. Wine, , M. Porteus

This study corrects multiple CFTR mutations in human airway stem cells using CRISPR/Cas9 and AAV vectors, achieving functional restoration in differentiated epithelial cells.

bioRxiv · Feb 26, 2021Bioengineering

Highly Efficient Repair of the ΔF508 Mutation in Airway Stem Cells of Cystic Fibrosis Patients with Functional Rescue of the Differentiated Epithelia

S. Vaidyanathan, A. A. Salahudeen, Z. M. Sellers, D. T. Bravo, S. S. Choi, A. Batish, W. Le, S. De La O, M. P. Kaushik, N. Galper, C. M. Lee, G. Bao, E. H. Chang, J. J. Wine, C. E. Milla, , M. H. Porteus

This paper corrects the ΔF508 mutation in CF patient airway stem cells using CRISPR-Cas9 and AAV6, achieving high correction rates and functional rescue in differentiated epithelia.

bioRxiv · Feb 26, 2019 · PreprintBioengineering