Author

S. J. Hachey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. C. Hughes· 3 shared C. J. Hatch· 2 shared K. Kessenbrock· 2 shared K. Nee· 2 shared A. Mocherla· 1 shared A. P. Lee· 1 shared A. Tankazyan· 1 shared D. A. Lawson· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

C. C. Hughes

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Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivSep 6, 2023

Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model

S. J. Hachey, C. J. Hatch, D. Gaebler…·C. C. Hughes

The paper uses a vascularized micro-tumor model to identify therapeutic targets in TNBC stromal interactions, showing efficacy of Tie2 and Her3/Akt inhibition.

DOI 10.1186/s13058-023-01760-y

humanscRNA-seq

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Cell BiologybioRxivPreprintOct 28, 2022

Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

K. V. Nguyen Ngoc, S. Sai, Y. Jun…·M. Sander

This study shows that engineered vasculature enhances the function of stem cell-derived islet organoids by improving calcium influx and insulin secretion in beta-cells.

DOI 10.1101/2022.10.28.513298

humanscRNA-seq

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Cancer BiologybioRxivMar 3, 2020

An In Vitro Vascularized Micro-Tumor Model of Human Colorectal Cancer Recapitulates In Vivo Drug Responses

S. J. Hachey, S. Movsesyan, Q. H. Nguyen…·C. C. Hughes

This paper validates a vascularized micro-tumor model for colorectal cancer that better replicates in vivo drug responses than traditional 2D or 3D models.

DOI 10.1039/d0lc01216e

humanorganoid / primary culture

𝕏 PostBluesky