K. Kessenbrock

The paper uses a vascularized micro-tumor model to identify therapeutic targets in TNBC stromal interactions, showing efficacy of Tie2 and Her3/Akt inhibition.

The paper shows pre-neoplastic stromal cells promote BRCA1-driven breast cancer by inducing epithelial proliferation and altering differentiation.

This study shows that Rasgrp1 fine-tunes EGFR signals in mammary epithelial cells to regulate development during puberty, with in vitro and in vivo effects on proliferation, branching, and cellularity.

This paper develops a 3D tumor sphere culture-transplant system to study human breast cancer metastasis using patient-derived xenografts and validates its utility for functional metastasis assays.

This paper validates a vascularized micro-tumor model for colorectal cancer that better replicates in vivo drug responses than traditional 2D or 3D models.

The paper integrates single-cell transcriptomics and chromatin accessibility analysis to identify novel regulatory elements in mouse mammary epithelial cells and their differentiation states.

This study identifies unique molecular features of MDSCs using single-cell transcriptomics, revealing a distinct maturation trajectory and novel surface markers for their detection.