Author

K. Nee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

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Organism:human· 5 Research Focus:cell type annotation· 4 Assay:scRNA-seq· 4 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2

Frequent Co-Authors

K. Kessenbrock· 4 shared N. Pervolarakis· 3 shared C. C. Hughes· 2 shared D. Ma· 2 shared G. Hernandez· 2 shared H. Alshetaiwi· 2 shared J. Wu· 2 shared M. L. Waterman· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

K. Kessenbrock

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5 papers

Recent·Most cited

Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor Microenvironments

L. Hosohama, D. F. Tifrea, K. Nee, S. Y. Park, J. Wu, A. N. Habowski, C. Van, M. M. Seldin, R. A. Edwards, M. L. Waterman

The paper isolates and characterizes two colorectal cancer stem cell subtypes, showing they create distinct tumor microenvironments and unify existing CRC classifications.

bioRxiv · Apr 25, 2024 · PreprintCancer Biology

Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model

S. J. Hachey, C. J. Hatch, D. Gaebler, A. Mocherla, K. Nee, K. Kessenbrock, C. C. Hughes

The paper uses a vascularized micro-tumor model to identify therapeutic targets in TNBC stromal interactions, showing efficacy of Tie2 and Her3/Akt inhibition.

bioRxiv · Sep 6, 2023Cancer Biology

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis

K. Nee, D. Ma, Q. H. Nguyen, N. Pervolarakis, J. Insua-Rodriguez, M. Pein, Y. Gong, G. Hernandez, H. Alshetaiwi, J. Williams, M. Rauf, K. R. Dave, K. Boyapati, C. Calderon, A. Markaryan, , K. Kessenbrock

The paper shows pre-neoplastic stromal cells promote BRCA1-driven breast cancer by inducing epithelial proliferation and altering differentiation.

bioRxiv · Oct 20, 2021 · PreprintCancer Biology

An In Vitro Vascularized Micro-Tumor Model of Human Colorectal Cancer Recapitulates In Vivo Drug Responses

S. J. Hachey, S. Movsesyan, Q. H. Nguyen, G. Burton-Sojo, A. Tankazyan, J. Wu, T. Hoang, M. M. Hatch, D. Zhao, E. Celaya, S. Gomez, G. T. Chen, R. T. Davis, K. Nee, N. Pervolarakis, , C. C. Hughes

This paper validates a vascularized micro-tumor model for colorectal cancer that better replicates in vivo drug responses than traditional 2D or 3D models.

bioRxiv · Mar 3, 2020Cancer Biology

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

H. Alshetaiwi, N. Pervolarakis, L. L. McIntyre, D. Ma, Q. Nguyen, J. A. Rath, K. Nee, G. Hernandez, K. Evans, L. Torosian, A. Silva, C. Walsh, K. Kessenbrock

This study identifies unique molecular features of MDSCs using single-cell transcriptomics, revealing a distinct maturation trajectory and novel surface markers for their detection.

bioRxiv · Jul 15, 2019Cancer Biology