Author

S. Sai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Physiology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Approach:statistical model· 4 Organism:mouse· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

H. Zhu· 2 shared M. Sander· 2 shared M. Schlichting· 2 shared R. O. Vidal· 2 shared S. Sauer· 2 shared A. A. Kuehl· 1 shared A. J. Rutkowski· 1 shared A. Petersen· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPhysiology

H. Zhu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2

M. Wortham, B. Ramms, C. Zeng, J. R. Benthuysen, S. Sai, D. P. Pollow, F. Liu, M. Schlichting, A. R. Harrington, B. Liu, T. P. Prakash, E. C. Pirie, H. Zhu, S. Baghdasarian, J. Auwerx, , M. Sander

This study identifies SIRT2 as a regulator of β-cell proliferation, showing its role in controlling β-cell expansion during hyperglycemia while preserving feedback mechanisms.

bioRxiv · Feb 24, 2024 · PreprintPhysiology

In situ Patch-seq analysis of microglia reveals a lack of stress genes as found in FACS-isolated microglia

O. Bakina, T. Conrad, N. Mitic, R. O. Vidal, T. Obrusnik, S. Sai, C. Nolte, M. Semtner, H. Kettenmann

The paper uses patch-seq to analyze microglia in situ and finds they lack stress-related genes compared to FACS-isolated microglia.

bioRxiv · Mar 22, 2023 · PreprintImmunology

Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

K. V. Nguyen Ngoc, S. Sai, Y. Jun, R. H. F. Bender, V. Kravets, H. Zhu, C. J. Hatch, M. Schlichting, R. Gaetani, M. Mallick, S. J. Hachey, K. Christman, S. C. George, C. C. Hughes, M. Sander

This study shows that engineered vasculature enhances the function of stem cell-derived islet organoids by improving calcium influx and insulin secretion in beta-cells.

bioRxiv · Oct 28, 2022 · PreprintCell Biology

Cell Atlas at Single-Nuclei Resolution of the Adult Human Adrenal Gland and Adrenocortical Adenomas

B. Altieri, K. Secener, S. Sai, C. Fischer, S. Sbiera, P. Arampatzi, S. Herterich, L.-S. Landwehr, S. Vitcetz, C. Braeuning, M. Fassnacht, C. Ronchi, S. Sauer

This study creates a single-nuclei cell atlas of the adult human adrenal gland and adrenocortical adenomas, revealing progenitor cell populations and tumor heterogeneity.

bioRxiv · Aug 27, 2022Physiology

TCAIM controls effector T cell generation by preventing Mitochondria-Endoplasmic Reticulum Contact Site-initiated Cholesterol Biosynthesis

C. Iwert, J. Stein, C. Appelt, K. Vogt, R. J. Rainer, K. Tummler, K. Muehle, K. Stanko, J. Schumann, D. Uebe, K. Juerchott, J. Lisec, K. Janek, C. Gille, K. Textoris-Taube, , B. Sawitzki

This study shows TCAIM prevents effector T cell differentiation by inhibiting mitochondria-ER contact sites that drive cholesterol biosynthesis and HIF1 activation.

bioRxiv · Apr 20, 2021 · PreprintImmunology

Dissecting HSV-1-induced host shut-off at RNA level

C. C. Friedel, A. W. Whisnant, L. Djakovic, A. J. Rutkowski, M.-S. Friedl, M. Kluge, J. C. Williamson, S. Sai, R. O. Vidal, S. Sauer, T. Hennig, B. Prusty, P. J. Lehner, N. J. Matheson, F. Erhard, L. Dölken

This study quantifies HSV-1-induced host shut-off mechanisms and identifies gene-specific transcriptional changes during early infection.

bioRxiv · May 20, 2020 · PreprintMicrobiology