S. M. Hinshaw

The paper determines the crystal structure of a Cse4 peptide bound to the Okp1-Ame1 heterodimer in budding yeast, revealing key interactions essential for centromere recognition.

This study demonstrates the use of KLHDC2 as a substrate adaptor for targeted protein degradation using peptide-based bivalent compounds.

The paper identifies multi-site phosphorylation of Mif2/CENP-C as essential for inner kinetochore assembly and accurate chromosome segregation in yeast.

This study presents crystal structures of SARS-CoV-2 Mpro bound to viral substrate peptides, revealing how peptide sequences influence catalytic efficiency and providing insights for antiviral drug design.

This study identifies a mechanism for regulated kinetochore sumoylation by showing that Ulp2 recruitment to Ctf3/CENP-I controls sumoylation levels and chromosome segregation.

This study presents a high-resolution structure of the Ctf3 complex bound to Cnn1-Wip1, revealing their role in kinetochore stabilization and feedback regulation across yeast and vertebrates.

The paper reports a near-atomic model of the yeast Ctf3 complex using cryo-EM, providing insights into its recruitment and function.