Acute irradiation alters the heterogeneity among medullary thymic epithelial cells 2
K. Horie, K. Namiki, M. Miyauchi, T. Ishikawa, M. Hayama, Y. Maruyama, T. Miyao, S. Murata, N. Akiyama, T. Akiyama
This study shows acute irradiation reduces AIRE-expressing mTECs and a unique Ccl25+ TSA-high mTEC cluster, altering mTEC heterogeneity and potentially impairing T cell self-tolerance.
bioRxiv · Apr 3, 2023Immunology