Y. Murakami

IGSF3 is a homophilic cell adhesion molecule that drives lung metastasis of melanoma by promoting adhesion to vascular endothelium

Polymeric nature of tandemly repeated genes enhances assembly of constitutive heterochromatin in fission yeast

The paper develops a theory explaining how tandemly repeated genes in fission yeast contribute to heterochromatin assembly through small RNA production and histone methylation.

Requirement of sequential hydrolysis by CD73 and ALP for uptake of vitamin B2 into cells

The paper shows that CD73 and ALP sequentially hydrolyze FAD to riboflavin, which is then taken up by cells, and this process is impaired in GPI-deficient cells.

Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an anti-silencing factor Epe1 in fission yeast

Predicting gene expression from cell morphology in human induced pluripotent stem cells

The paper builds a model to predict gene expression from cell morphology in hiPSCs and identifies two genes well-predicted by morphology.

Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation models

This paper evaluates four commonly used murine models of atrial fibrillation and finds they do not exhibit authentic AF characteristics, such as micro-reentrant circuits or typical ECG features.

CLPTM1L is a lipid scramblase involved in glycosylphosphatidylinositol biosynthesis

The paper identifies CLPTM1L as a lipid scramblase essential for translocating glucosaminyl-phosphatidylinositol across the ER membrane during GPI biosynthesis.

Reprogramming and redifferentiation of mucosal-associated invariant T cells reveals tumor inhibitory activity

The paper reprograms and redifferentiates murine MAIT cells into m-reMAIT cells to study their tumor inhibitory activity, showing they enhance survival via NK cell-mediated cytotoxicity.

Drug metabolism activity is a Critical Intrinsic Selector for Hepatocytes to elongate cell lifespan by using a cell-killing antibiotic

This study develops a method to expand human hepatocytes in vitro using a cell-killing antibiotic, enabling long-term culture and stable supply for drug research.

Combined landscape of single-nucleotide variants and copy-number alterations in clonal hematopoiesis

The paper combines SNVs/indels and CNAs analysis in CH to show their co-occurrence and impact on health outcomes.

Involvement of I-BAR protein IRSp53 in tumor cell growth via extracellular microvesicle secretion

This study shows IRSp53 promotes tumor cell proliferation through microvesicle secretion, as evidenced by reduced secretion and phosphorylation in knockout cells and increased survival in IRSp53-deficient mice.

Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7

This study shows that TLR7 activation by accumulated nucleosides in lysosomes drives histiocytosis in SLC29A3 disorders.

Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation

The paper identifies B3GALT4's dual role in GPI and glycosphingolipid biosynthesis and shows ER-associated degradation suppresses GPI biosynthesis when GPI transfer to proteins is defective.

Complement- and inflammasome-mediated autoinflammation-paroxysmal nocturnal hemoglobinuria

This study identifies AIF-PNH as a disease caused by germline and somatic mutations in PIGT, leading to complement activation and inflammasome-mediated IL-1β secretion, which is treatable with eculizumab.