Author

M. Osato

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Hoellein· 1 shared A. Jahn· 1 shared A. Knaus· 1 shared B. Hoechsmann· 1 shared B. Novak· 1 shared D. G. Tenen· 1 shared D. Kappei· 1 shared D. L. Mobley· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperImmunology

A. Hoellein

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression

G. Rane, V. L. S. Kuan, S. Wang, M. M. H. Mok, V. Khanchandani, J. Hansen, I. Norvaisaite, W. K. Yong, A. Jahn, V. Mukundan, Y. Shi, M. Osato, F. Li, D. Kappei

This study identifies ZBTB48 as a transcription factor that regulates B-cell-specific CIITA expression by binding to its promoter and establishing open chromatin.

bioRxiv · Jul 25, 2023Immunology

POPSHIFT: A THERMODYNAMICALLY SOUND APPROACH TO ESTIMATE BINDING FREE ENERGIES BY ACCOUNTING FOR LIGAND-INDUCED POPULATION SHIFTS FROM A LIGAND-FREE MSM

L. G. Smith, B. Novak, M. Osato, D. L. Mobley, G. R. Bowman

The paper introduces PopShift, a method to estimate binding free energies by accounting for ligand-induced population shifts in protein conformations using Markov state models, showing improved accuracy over traditional methods.

bioRxiv · Jul 14, 2023 · PreprintBiophysics

ADAR2-repressed RNA editing: a novel mechanism contributing to t (8:21) AML leukemogenesis

M. Guo, T. H. M. Chan, O. An, Y. Song, Z. H. Tan, V. H. E. Ng, X. Cao, W. J. Chng, M. Osato, H. Yang, Q. Zhou, L. Chen, D. G. Tenen

This study identifies ADAR2 downregulation in t(8;21) AML and shows its role in suppressing leukemogenesis through RNA editing.

bioRxiv · Oct 18, 2021 · PreprintCancer Biology

Complement- and inflammasome-mediated autoinflammation-paroxysmal nocturnal hemoglobinuria

B. Hoechsmann, Y. Murakami, M. Osato, A. Knaus, M. Kawamoto, N. Inoue, T. Hirata, S. Murata, M. Anliker, T. Eggerman, M. Jaeger, R. Floettmann, A. Hoellein, S. Murase, Y. Ueda, , T. Kinoshita

This study identifies AIF-PNH as a disease caused by germline and somatic mutations in PIGT, leading to complement activation and inflammasome-mediated IL-1β secretion, which is treatable with eculizumab.

bioRxiv · May 13, 2019 · PreprintImmunology