S. R. Amend

The paper introduces a flow cytometry method to detect and analyze rare CTCs and DTCs in cancer metastasis models, enabling the study of metastatic barriers across multiple steps in a single model system.

This study uses a microfluidic device to induce drug resistance in TNBC cells and identifies the NUPR1/HDAC11 axis as a key factor in chemoresistance, correlating high Nupr1 expression with poor clinical outcomes.

This study identifies nuclear morphology and functional characteristics associated with cancer cell survival after cisplatin chemotherapy, highlighting the role of the polyaneuploid cancer cell (PACC) state in treatment resistance.

The paper identifies Polyaneuploid Cancer Cells (PACCs) as metastasis-competent cells through increased motility, elasticity, and survival in circulation.