Sphingosine 1-phosphate receptor 1 inhibition induces a pro-apoptotic signaling cascade in T cells
D. Dixit, V. M. Hallisey, E. Y. S. Zhu…·S. R. Schwab
This study shows that S1PR1 inhibition leads to T cell apoptosis by altering BCL2 family balance and JNK activity, with implications for immune responses in ulcerative colitis.