S. T. Cole

This study discovers two novel polyglycosylated thiopeptides, persiathiacins A and B, active against drug-resistant tuberculosis and identifies their biosynthetic gene cluster.

The paper reports leprosy-like lesions in wild chimpanzees and identifies M. leprae strains with rare genotypes, suggesting multiple introductions from an unknown source.

This study identifies EccE1 as a critical membrane protein required for ESX-1 function and stabilization of ESX-1 membrane proteins in Mycobacterium tuberculosis, with deletion of eccE1 reducing levels of other ESX-1 components and attenuating bacterial virulence.

The paper designs and characterizes sulfonyl-piperazine benzothiazinone inhibitors of DprE1 from M. tuberculosis, finding they have improved solubility but lower activity than MCZ.