H. Ito

Targeting fatty acid synthase suppresses tumor development in NF2/CDKN2A-deficient malignant pleural mesothelioma

This study identifies FASN inhibition as a therapeutic strategy for NF2/CDKN2A-deficient MPM, showing reduced tumor growth in xenograft models.

Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate incorporation of CD63 in multivesicular bodies

This study investigates the role of ADAP1 and ARAP1 in CD63 incorporation into multivesicular body intralumenal vesicles and shows their differential regulation of CD63 localization.

Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection

This study introduces AkaBLI, a method using Akaluc bioluminescence to track SARS-CoV-2 infection in vivo with higher sensitivity than NanoLuc, showing its utility in monitoring viral dynamics and vaccine efficacy.

Variability in radiocesium activity concentration in growing hardwood shoots in Fukushima, Japan

The paper models radiocesium activity concentration variability in hardwood shoots to determine an optimal sample size for accurate estimation.

Complete suspension culture of human induced pluripotent stem cells supplemented with suppressors of spontaneous differentiation

This study develops a suspension culture method for hiPSCs using PKCβ and Wnt inhibitors to prevent spontaneous differentiation, enabling scalable and stable clinical-grade hiPSC production.

The exogenous application of the apocarotenoid retinaldehyde negatively regulates auxin-mediated root growth

Short-term inhibition of carotenoid biosynthesis increases retinal levels, which reduce auxin levels and signaling to suppress root growth.

Virological characteristics of the SARS-CoV-2 XBB.1.5 variant

The paper analyzes the virological characteristics of the SARS-CoV-2 XBB.1.5 variant, showing reduced pathogenicity and impaired MHC expression due to mutations in ORF8 and S.

Automated escape system: identifying prey's kinematic and behavioral features critical for predator evasion

This study develops an automated escape system to identify prey kinematic and behavioral features critical for predator evasion, showing that escape speed and reaction distance significantly affect predator-prey interactions.

Reconstitution of C9orf72 (GGGGCC) repeat-associated non-AUG translation with purified components.

This study reconstitutes G4C2 repeat-associated non-AUG translation using purified human factors and identifies key features of the process.

Convergent evolution of the SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

The paper investigates convergent evolution in SARS-CoV-2 Omicron subvariants, identifying five critical spike protein substitutions in BQ.1.1 that enhance viral fitness and antibody resistance.

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

This study compares the pathogenicity of SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.5, finding BA.5 is more fusogenic and induces stronger inflammation than earlier variants.

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.2.12.1, BA.4 and BA.5

This study analyzes the virological characteristics of SARS-CoV-2 Omicron variants BA.2.12.1, BA.4, and BA.5, finding they have higher reproduction numbers, reduced neutralization by prior immunity, increased replication in lung cells, and greater pathogenicity in hamsters compared to BA.2.

Evolution of self-sustained circadian rhythms requires seasonal change of daylight

This study shows that seasonality promotes the evolution of self-sustained circadian rhythms through computational modeling of gene regulatory networks under light cycles.

Virological characteristics of SARS-CoV-2 BA.2 variant

This study compares the virological characteristics of SARS-CoV-2 BA.2 and BA.1 variants, finding BA.2 has higher transmissibility, different antigenicity, greater replicative capacity, and higher pathogenicity in hamsters.

AI boosted molecular MRI for apoptosis detection in oncolytic virotherapy

This paper introduces an AI-enhanced molecular MRI technique to detect apoptosis in oncolytic virotherapy, showing early detection of apoptotic response in a glioblastoma model and clinical validation in a human subject.

Generation of iPSCs from endangered Grevy's zebra and comparative transcriptomic analysis of mammalian PSCs

This study generates iPSCs from Grevy's zebra and compares their transcriptome to other mammalian PSCs, revealing evolutionary conservation and species-specific variation in pluripotency genes.

Inhibition of immunoglobulin class-switching prevents pemphigus onset in desmoglein 3-specific B cell receptor knock-in mouse

This study shows that inhibiting immunoglobulin class-switching prevents pemphigus onset in mice, with FcγRIIB signaling attenuation contributing to disease.

Genomic imprinting drives eusociality

This paper proposes a genomic imprinting theory to explain the evolution of eusociality from subsocial ancestors by linking parental reproductive capacity to delayed offspring sexual development through transgenerational epigenetic marks.

Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocyte accumulating hepatitis B surface antigen

Redesigned Reporter Gene for Improved Proton Exchange-based Molecular MRI Contrast

The paper redesigns a reporter gene to improve CEST MRI contrast by reducing DNA recombination and enhancing stability and sensitivity.

Combined impact of pesticides and other environmental stressors on taxonomic richness of freshwater animals in irrigation ponds

The paper assesses how pesticides and environmental stressors affect taxonomic richness in freshwater animals in irrigation ponds, identifying specific stressors and their interactions.

Seasonal and annual fluctuations of deer populations estimated by a Bayesian state-space model

This study uses a Bayesian state-space model to estimate seasonal and annual fluctuations in sika deer populations in Japan, identifying factors like snowfall and nuisance control affecting population dynamics.