Author

S. Vanharanta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

C. Frezza· 2 shared C. Schmidt· 2 shared G. D. Stewart· 2 shared M. Yang· 2 shared V. Caraffini· 2 shared A. Dugourd· 1 shared A. Erez· 1 shared A. N. Mora· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

C. Frezza

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

HIRA loss transforms FH-deficient cells

L. Valcarcel-Jimenez, C. Rogerson, C. Yong, C. Schmidt, M. Yang, V. Harle, V. Offord, K. Wong, A. N. Mora, A. Speed, V. Caraffini, M. G. B. Tran, E. R. Maher, G. D. Stewart, S. Vanharanta, , C. Frezza

This study identifies HIRA depletion as a factor that enhances proliferation and invasion of Fh1-deficient cells, revealing a mechanism involving MYC activation and nucleotide metabolism.

bioRxiv · Jun 4, 2022Cancer Biology

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

M. Sciacovelli, A. Dugourd, L. Valcarcel Jimenez, M. Yang, E. Nikitopoulou, A. S. Costa, L. Tronci, V. Caraffini, P. Rodrigues, C. Schmidt, D. G. Ryan, T. Young, V. Zecchini, S. H. Rossi, C. Massie, , C. Frezza

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

bioRxiv · Sep 17, 2021 · PreprintCancer Biology