Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation
Y. Kim, K.-Y. Jung, Y. H. Kim, P. Xu, Y. Jo, B. E. Kang, N. Pandit, J. Kwon, K. Gariani, J. Gariani, J. Lee, J. Verbeek, S. Nam, S.-J. Bae, K.-T. Ha, , J. Auwerx
This study shows that SIRT7 contributes to sorafenib resistance in HCC by enhancing ERK phosphorylation, and inhibiting SIRT7 with sorafenib reduces tumor growth.
bioRxiv · Mar 13, 2023 · PreprintCancer Biology