C.-W. Lee

MiR-221/222-enriched ADSC-exosome mitigates PM exposure-exacerbated cardiac ischemia/reperfusion injury through the modulation of the BNIP3/LC3B/PUMA pathway

This study shows that PM exposure worsens cardiac ischemia/reperfusion injury, which is mitigated by ADSC-exosome containing miR-221/222 through modulation of the BNIP3/LC3B/PUMA pathway.

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

This study shows that SIRT7 contributes to sorafenib resistance in HCC by enhancing ERK phosphorylation, and inhibiting SIRT7 with sorafenib reduces tumor growth.

The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7

This study determines the structure of MBOAT7, models its catalytic mechanism, and identifies potential inhibitors for therapeutic development.

In situ structural analysis reveals membrane shape transitions during autophagosome formation

This study uses cryo-electron tomography to analyze autophagosome formation in yeast, revealing membrane shape transitions and interactions during biogenesis.

Identification of two pathways mediating protein targeting from ER to lipid droplets

The paper identifies two distinct pathways for ER-to-LD protein targeting and characterizes the molecular machinery involved.

In cell architecture of the nuclear pore complex and snapshots of its turnover

The paper uses structural biology and yeast genetics to study NPC architecture and turnover in yeast cells, revealing new insights into mRNA export and autophagy mechanisms.

A selective autophagy pathway for phase separated endocytic protein deposits

The paper identifies Ede1 as a selective autophagy receptor for endocytic protein condensates, showing its role in phase separation and autophagic degradation.

Phosphorylation of the exocyst subunit Exo70B2 contributes to the regulation of its function

This study shows that phosphorylation of Exo70B2 regulates its function in secretion and immunity by modulating its localization and interaction with the secretory pathway.

Cryo-EM Structure of OSCA1.2 from Oryza sativa: Mechanical basis of hyperosmolality-gating in Plants

The paper reports the cryo-EM structure of OsOSCA1.2 from rice, revealing its mechanism for sensing hyperosmolality and mediating ion permeability through structural dynamics.