Y. Jo

Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection

This study identifies LDHB as a key regulator of pDC IFN-I production and metabolic capacity during viral infection, linking metabolic deficiencies to pDC exhaustion and its dual role in immunity and pathology.

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

This study shows that SIRT7 contributes to sorafenib resistance in HCC by enhancing ERK phosphorylation, and inhibiting SIRT7 with sorafenib reduces tumor growth.

Induced CD45 Proximity Potentiates Natural Killer Cell Receptor Antagonism

This study shows that CD45-linked NKR antagonists enhance NK and T cell activity more than traditional antibodies, revealing potential for improved cancer immunotherapies.

L-threonine mediated DAF-16/HSF-1 activation inhibits ferroptosis and increases healthspan

This study shows L-threonine supplementation increases C. elegans healthspan by inhibiting ferroptosis via DAF-16 and HSF-1 pathways.

Label-free adaptive optics single-molecule localization microscopy for whole animals

This paper develops a label-free adaptive optics method for SMLM, enabling deep-tissue super-resolution imaging in whole animals by correcting tissue aberrations.

Rapid label-free identification of pathogenic bacteria species from a minute quantity 1 exploiting three-dimensional quantitative phase imaging and artificial neural network

This paper develops a framework for rapid bacterial species identification using 3D quantitative phase imaging and artificial neural networks, achieving 99.9% accuracy with single colony-forming units.

Data-driven multiplexed microtomography of endogenous subcellular dynamics

This paper introduces a data-driven method for multiplexed microtomography using refractive index imaging to study endogenous subcellular dynamics without exogenous labels.

Identification of viruses belonging to the family Partitiviridae from plant transcriptomes

This study identifies 23 partitiviruses from 11 plant species using transcriptomes, finding 74 RNA segments with 28 encoding RdRp and 46 encoding CP.

Identification of viruses from fungal transcriptomes

This study identifies mycoviruses from fungal transcriptomes, revealing their diversity, host distribution, and complex population dynamics.

Although host-related factors are important for the formation of gut microbiota, environmental factors cannot be ignored

This study compares host-related factors and environmental factors in shaping gut microbiota using fecal samples from naval trainees and healthy individuals, finding host factors more influential.

DeepIS: deep learning framework for three-dimensional label-free tracking of immunological synapses

This paper introduces a deep learning framework for 3D label-free tracking of immunological synapses using optical diffraction tomography and segmentation.

Deep-learning-based label-free segmentation of cell nuclei in time-lapse refractive index tomograms

This paper introduces a deep learning method for label-free cell nucleus segmentation in time-lapse refractive index tomograms, validated across multiple experiments.

Learning-based screening of hematologic disorders using quantitative phase imaging of individual red blood cells

This paper develops a label-free method using quantitative phase imaging and machine learning to screen for hematologic disorders with high accuracy.

Holographic deep learning for rapid optical screening of anthrax spores

This paper develops a deep learning method using holographic microscopy to rapidly and accurately classify anthrax spores and other pathogens.

Label-free identification of non-activated lymphocytes using three-dimensional refractive index tomography and machine learning

This study identifies non-activated lymphocyte subtypes using label-free refractive index tomography and machine learning with high specificity and sensitivity.