Author

T. Brady

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

H. Wang· 2 shared J. Steppan· 2 shared K. Nandakumar· 2 shared L. Santhanam· 2 shared A. Greaney· 1 shared A. Poe· 1 shared A. S. Dingens· 1 shared B. Case· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPhysiology

H. Wang

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Author profile →

3 papers

Recent·Most cited

Sex Differences and Role of Lysyl Oxidase Like 2 (LOXL2) in Angiotensin II-Induced Hypertension in Mice

L. Santhanam, H. Wang, M. M. Yus, T. Brady, R. Choi, K. Nandakumar, L. Smith, R. Jang, B. P. Wodu, J. D. Almodiel, L. Stoddart, D.-H. Kim, J. Steppan

This study investigates sex differences and the role of LOXL2 in Ang II-induced hypertension, finding that LOXL2 depletion protects males but worsens female aortic contractility.

bioRxiv · Dec 13, 2023Physiology

LOXL2 inhibition ameliorates pulmonary artery remodeling in pulmonary hypertension

J. Steppan, H. Wang, K. Nandakumar, A. Poe, L. Pak, T. Brady, M. Gadkari, D. E. Berkowitz, L. A. Shimoda, L. Santhanam

This study shows LOXL2 inhibition reduces pulmonary artery stiffness and improves survival in pulmonary hypertension models.

bioRxiv · Oct 24, 2023Physiology

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

J. Dong, S. Zost, A. Greaney, T. N. Starr, A. S. Dingens, E. C. Chen, R. Chen, B. Case, R. Sutton, P. Gilchuk, J. Rodriguez, E. Armstrong, C. Gainza, R. Nargi, E. Binshtein, , J. E. Crowe

This paper determines the structures of two antibodies in the AZD7442 cocktail that neutralize SARS-CoV-2 and identifies critical residues for neutralization and viral escape.

bioRxiv · Jan 27, 2021 · PreprintImmunology