Author

R. Sutton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

E. Binshtein· 2 shared E. C. Chen· 2 shared J. E. Crowe· 2 shared M. Diamond· 2 shared P. Gilchuk· 2 shared R. Chen· 2 shared R. Nargi· 2 shared S. Zost· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

E. Binshtein

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mutational and transcriptional landscape of pediatric B-cell precursor lymphoblastic lymphoma

E. Kroeze, I. Iaccarino, M. M. Kleisman, M. Mondal, T. Beder, M. Khouja, M. P. Hoeppner, M. Scheijde-Vermeulen, L. A. Kester, M. Brueggemann, C. D. Baldus, G. Cario, R. S. Bladergroen, N. Garnier, A. Attarbaschi, , W. Klapper

This study presents the first comprehensive mutational and transcriptional analysis of B-cell precursor lymphoblastic lymphoma (BCP-LBL), revealing molecular similarities to BCP-ALL but with distinct mutation patterns in epigenetic modifiers.

bioRxiv · Dec 27, 2023Cancer Biology

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

L. Peng, Y. Hu, M. Mankowski, P. Ren, R. Chen, J. Wei, M. Zhao, T. Li, T. Tripler, L. Ye, R. Chow, Z. Fang, C. Wu, M. Dong, M. Cook, , S. Chen

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

bioRxiv · Dec 21, 2021Immunology

Untargeted 1H NMR Metabolomics and Pathway Analysis Reveals Dysregulated Proteostasis in Cyclophilin D (CypD)-deficient Mice Tissues

Y. I. Adegbite, O. S. Adegbite, Y. Ouyang, R. Sutton, D. N. Criddle, L.-Y. Lian

This study uses metabolomics to show that CypD deficiency disrupts protein homeostasis and metabolic pathways in multiple tissues of mice.

bioRxiv · Apr 20, 2021 · PreprintBiochemistry

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

J. Dong, S. Zost, A. Greaney, T. N. Starr, A. S. Dingens, E. C. Chen, R. Chen, B. Case, R. Sutton, P. Gilchuk, J. Rodriguez, E. Armstrong, C. Gainza, R. Nargi, E. Binshtein, , J. E. Crowe

This paper determines the structures of two antibodies in the AZD7442 cocktail that neutralize SARS-CoV-2 and identifies critical residues for neutralization and viral escape.

bioRxiv · Jan 27, 2021 · PreprintImmunology

Neutralizing and protective human monoclonal antibodies recognizing the N-terminaldomain of the SARS-CoV-2 spike protein

N. Suryadevara, S. Shrihari, P. Gilchuk, L. VanBlargan, E. Binshtein, S. Zost, R. Nargi, R. Sutton, E. S. Winkler, E. C. Chen, M. E. Fouch, E. Davidson, B. Doranz, R. H. Carnahan, L. Thackray, , J. E. Crowe

The paper identifies two NTD-specific human mAbs with neutralizing activity against SARS-CoV-2 and shows they require Fc effector functions for optimal protection.

bioRxiv · Jan 19, 2021Immunology

The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies?

H. Tinning, A. Taylor, D. Wang, B. Constantinides, R. Sutton, G. Oikonomou, M. A. Velazquez, P. Thompson, A. Treumann, M. J. O'Connell, N. Forde

This study shows that CAPG, a conserved protein, induces transcriptional changes in endometrial cells of humans and cattle, potentially aiding implantation across species with different implantation strategies.

bioRxiv · Feb 19, 2020Physiology

The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis

Q. M. Nunes, D. Su, P. J. Brownridge, D. M. Simpson, C. Sun, y. li, P. T. P. Bui, X. Zhang, W. Huang, D. J. Rigden, R. J. Beynon, R. Sutton, D. G. Fernig

This study identifies extracellular heparin-binding proteins (HBPs) in normal and acute pancreatitis mouse pancreas and plasma, revealing their roles in homeostasis and inflammation.

PLOS ONE · Jun 18, 2019Peer-reviewedBiochemistry