L. Le

Instantly adhesive and ultra-elastic patches for dynamic organ and wound repair

This paper develops a bioadhesive patch with instant adhesion, ultra-elasticity, and therapeutic delivery capabilities for organ and wound repair.

A role for brassinosteroid signaling in decision-making processes in the Arabidopsis seedling

This study identifies brassinosteroid signaling mutants with altered decision-making in Arabidopsis seedlings under resource limitation, showing distinct growth strategies for hypocotyl and root development.

Membrane tension spatially organizes lysosomal exocytosis

This study shows that lysosomal exocytosis clusters spatially at the plasma membrane of RPE1 cells, driven by membrane tension patterns controlled by focal adhesions.

Stem cell-free therapy for glaucoma to preserve vision

This study demonstrates that stem cell-derived secretome reduces intraocular pressure and protects retinal ganglion cells in glaucoma models through COX2-PGE2 pathway activation and extracellular matrix remodeling.

Distant Residues Modulate Conformational Opening in SARS-CoV-2 Spike Protein

This paper identifies non-RBD residues in SARS-CoV-2 spike protein that modulate conformational changes critical for receptor binding, offering targets for broad-spectrum therapeutics.

A Newly Identified Role for IL-22 in Bladder Immunity

This study identifies IL-22's role in bladder immunity by showing its importance in epithelial maintenance and bacterial clearance during urinary tract infections.

SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation

This study identifies SLC45A2's role in melanosome pH regulation and pigmentation, showing its function in melanin synthesis and how a variant affects protein stability and pigmentation.

Interleukin-4 signaling plays a major role in urogenital schistosomiasis-associated bladder pathogenesis

This study shows IL-4 signaling is critical for bladder pathology in urogenital schistosomiasis, with IL-4 promoting urothelial proliferation and cell cycle changes.

Water storage and irrigation practices associated with cannabis production drive seasonal patterns of water extraction and use in Northern California watersheds

This study models how cannabis cultivation practices and stored water use affect seasonal water extraction patterns in Northern California watersheds.

NOD1 mediates non-canonical inflammasome processing of interleukin-18 in epithelial cells to Helicobacter pylori infection.

This study identifies NOD1 as a key regulator of IL-18 processing in epithelial cells during Helicobacter pylori infection, independent of canonical inflammasome proteins.

IPSE, a parasite-derived host immunomodulatory protein, is a promising therapeutic for hemorrhagic cystitis

This paper demonstrates that H-IPSEH03, a parasite-derived protein, is effective in treating hemorrhagic cystitis by reducing bladder inflammation and promoting urothelial proliferation.

IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways

This study identifies IPSE's mechanism in reducing ifosfamide-induced cystitis by downregulating pro-inflammatory pathways and oxidative stress responses in mouse bladders.