T. L. Denning

Modulatory Effects of IFN-γ and IL-22 on Inflammatory Signaling and Cellular Responses in Intestinal Epithelial Cells

This study investigates how IFN-γ and IL-22 interact in intestinal epithelial cells, showing that their combination can shift IL-22's role from anti-inflammatory to pro-inflammatory.

IL-36/IL-36R Signaling Promotes CD4+ T Cell-Dependent Colitis via Pro-Inflammatory Cytokine Production

This study shows IL-36γ promotes colitis by enhancing CD4+ T cell cytokine production, specifically IFNγ and TNF, and suggests targeting these cytokines as a therapeutic strategy for IBD.

Methyltransferase SMYD5 Exaggerates IBD by Downregulating Mitochondrial Functions via Post-translational Control of PGC-1α Stability

This study identifies SMYD5 as a driver of IBD by downregulating mitochondrial functions through methylation-dependent degradation of PGC-1α in intestinal epithelial cells.