T. Lo

The high-resolution in vivo measurement of replication fork velocity and pausing by lag-time analysis

This paper introduces lag-time analysis to measure replication fork velocity and pausing in vivo, finding locus- and time-dependent dynamics and novel pauses at rDNA.

Sleeve gastrectomy promotes colitis-associated colorectal cancer in a murine model via a modified gut microbiome

This study shows that sleeve gastrectomy worsens colitis-associated colorectal cancer in mice by altering the gut microbiome, which can independently promote tumor growth.

Characterizing stochastic cell cycle dynamics in exponential growth

The paper establishes an exact correspondence between deterministic and stochastic cell cycle models, showing deterministic models can well-fit exponential culture demographics even with stochastic state timing.

Daily transient coating of the intestine leads to weight loss and improved glucose tolerance

This study shows that daily administration of LuCI, an oral gut coating agent, leads to weight loss and improved insulin sensitivity in a rat model of diet-induced obesity.

Noise Reconstruction & Removal Network: A New Architecture to Denoise FIB-SEM Images

The paper introduces an unsupervised Noise Reconstruction and Removal Network for denoising FIB-SEM images, achieving results comparable to or better than supervised methods.

Restored TDCA and Valine Levels Imitate the Effects of Bariatric Surgery

The paper shows that restoring TDCA and valine levels in obese mice mimics the weight loss effects of bariatric surgery.

Yeast Genomic Screens Identify Kinesins as Potential Targets of the Pseudomonas syringae Type III Effector, HopZ1a

The paper identifies HopZ1a, a T3SE from Pseudomonas syringae, as an acetyltransferase that targets plant kinesins to disrupt microtubule networks through yeast genetic and interaction screens.