J. Y. Lee

The paper predicts Drosophila glial transcripts involved in synaptic plasticity by analyzing mammalian glial transcriptomes and validates their localization and functional importance.

This paper introduces an algorithm called cryoRL that uses reinforcement learning to optimize cryo-EM data collection, outperforming human operators in efficiency and image quality.

The paper systematically analyzes YFP gene traps in Drosophila to show widespread discordance between mRNA and protein expression in the nervous system, revealing common post-transcriptional regulation.

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.

The paper shows that aged microbiota causes leaky gut and inflammation by reducing butyrate and FFAR2/3, which weakens mucin barriers.

This paper identifies ONG41008 as a TGFβ biogenesis inhibitor with potent anti-fibrotic and anti-inflammatory effects in IPF and inflammatory models.

The paper quantifies SARS-CoV-2 RNA molecules using smFISH, revealing genomic RNA stability, cell-to-cell replication variability, and slower replication kinetics for the B.1.1.7 variant compared to the Victoria strain.

This paper develops an intranasal ASO therapy targeting SARS-CoV-2 RNA that effectively prevents viral replication in multiple models and variants.

This study examines strain variation in Bacillus cereus biofilms and their susceptibility to extracellular matrix-degrading enzymes, revealing distinct structural and compositional differences among strains.

The paper validates a single-step, single-tube RT-LAMP assay for rapid SARS-CoV-2 detection with high specificity and sensitivity.

This study uses single-molecule techniques to show that yeast CHD1 remodels nucleosomes through unique DNA unwrapping and translocation dynamics involving ATP binding and hydrolysis.

The paper uses single-molecule fluorescence to show that RNA release precedes RNA polymerase dissociation during bacterial intrinsic termination, revealing a recycling stage where RNAP diffuses and can reinitiate transcription.

The paper identifies extensive diversity in type I restriction modification systems in Staphylococcus epidermidis compared to Staphylococcus aureus, enabling efficient genetic manipulation of clinically relevant strains.

This study shows that mechanotransduction in breast cancer occurs without YAP, due to compact nuclear morphologies in vivo.