Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1
S. Abini-Agbomson, K. Gretarsson, R. M. Shih, L. Hsieh, T. Lou, P. De Ioannes, N. Vasilyev, R. Lee, M. Wang, M. Simon, J.-P. Armache, E. Nudler, G. Narlikar, S. Liu, C. Lu, K.-J. Armache
This study characterizes the catalytic and non-catalytic mechanisms of SUV420H1 by determining cryo-EM structures and showing its role in DNA accessibility and chromatin condensation.
bioRxiv · Mar 17, 2023Biochemistry