J.-P. Armache

Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking

Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1

This study characterizes the catalytic and non-catalytic mechanisms of SUV420H1 by determining cryo-EM structures and showing its role in DNA accessibility and chromatin condensation.

Cryo-EM structure of the human Sirtuin 6-nucleosome complex

The paper presents the cryo-EM structure of the human SIRT6-nucleosome complex, revealing how SIRT6 deacetylates histone H3 K9 and K56.

SARS-CoV-2 polyprotein substrate regulates the stepwise Mpro cleavage reaction

This study presents cryo-EM structures of SARS-CoV-2 Mpro bound to the nsp7-10 region of pp1a polyprotein, revealing how Mpro interacts with polyproteins and cleaves them sequentially.

Electron cryo-microscopy structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome.

The paper presents cryo-EM structures of SNF2h-nucleosome complexes with ADP-BeFx, revealing conformational states that suggest allosteric control through the nucleosome.

The structural basis for activation of voltage sensor domains in an ion channel TPC1

The paper presents four structures of the TPC1 ion channel's voltage sensor domain, revealing how activation occurs through conformational changes and Ca2+ binding.