Author

D. Mitchell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Animal Behavior & Cognition· 1 Biochemistry· 1 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

J. Huang· 2 shared J. N. Bembenek· 2 shared A. da Silva· 1 shared A. Doty· 1 shared A. F. Severson· 1 shared A. K. Sood· 1 shared A. Kotrschal· 1 shared A. L. Hunt· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 4 mutual co-author links

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2 shared papersBioengineering

J. Huang

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Securin Regulates the Spatiotemporal Dynamics of Separase

C. G. S. Turpin, D. Sloan, M. LaForest, L. U. Klebanow, D. Mitchell, A. F. Severson, J. N. Bembenek

The paper investigates how securin degradation by APC/C controls separase localization and function during meiosis I, showing its role in chromosome segregation and exocytosis.

bioRxiv · Dec 12, 2023 · PreprintCell Biology

Mutation signature filtering enables high-fidelity RNA structure probing at all four nucleobases with DMS

D. Mitchell, J. Cotter, I. Saleem, A. Mustoe

This paper improves DMS mutational profiling to probe RNA structure at all four nucleotides with high fidelity in cells.

bioRxiv · Apr 10, 2023 · PreprintBiochemistry

Three-Dimensional Bioconjugated Liquid-Like Solid (LLS) Enhance Characterization of Solid Tumor - Chimeric Antigen Receptor T cell Interactions

D. T. Nguyen, R. Liu, E. Ogando-Rivas, A. Pepe, D. Pedro, S. Qdaisat, T. Y. N. Nguyen, J. Lavrador, G. Golde, R. Smolcheck, J. Ligon, L. Jin, H. Tao, A. Webber, S. Phillpot, , W. G. Sawyer

This study uses 3D bioconjugated liquid-like solids to model tumor-immune interactions, showing CAR T cells can infiltrate and kill cancer cells while revealing immune escape mechanisms.

bioRxiv · Feb 17, 2023 · PreprintBioengineering

Human Surfactant Protein D Facilitates SARS-CoV-2 Pseudotype Binding and Entry in DC-SIGN Expressing Cells, and Downregulates Spike protein Induced Inflammation

N. Beirag, C. Kumar, T. Madan, M. H. Shamji, R. Bulla, D. Mitchell, V. Murugaiah, M. Mayora Neto, N. J. Temperton, S. Idicula-Thomas, P. M. Varghese, U. Kishore

This study shows that rfhSP-D enhances SARS-CoV-2 Spike protein binding to DC-SIGN and increases viral uptake in DC-SIGN-expressing cells while reducing inflammation.

bioRxiv · May 16, 2022Immunology

Jumping out of trouble: Evidence for a cognitive map in guppies (Poecilia reticulata)

H. de Waele, C. Vila Pouca, D. van Boerdonk, E. Luiten, L. M. Leenheer, D. Mitchell, R. Vega-Trejo, A. Kotrschal

This study shows guppies use spatial memory and environmental cues to direct jumps, using a cognitive map in familiar situations.

bioRxiv · Mar 30, 2022Animal Behavior & Cognition

Slow-cycling cells in glioblastoma: a specific population in the cellular mosaic of cancer stem cells

C. Yang, G. Tian, M. Dajac, A. Doty, S. Wang, J.-H. Lee, M. Rahman, J. Huang, B. A. Reynolds, M. R. Sarkisian, D. Mitchell, L. P. Deleyrolle

This study compares slow-cycling cells with cancer stem cell (CSC)-like cells in glioblastoma, showing phenotypic and functional heterogeneity and supporting the cancer stem cell mosaicism model.

bioRxiv · Jan 25, 2022Cancer Biology

Extensive Intratumor Proteogenomic Heterogeneity Revealed by Multiregion Sampling in High-Grade Serous Ovarian Tumor Specimens

A. L. Hunt, N. W. Bateman, W. Barakat, S. Makohon-Moore, B. L. Hood, K. A. Conrads, M. Zhou, V. Calvert, M. Pierobon, J. Loffredo, T. J. Litzi, J. Oliver, D. Mitchell, G. Gist, C. Rojas, , T. P. Conrads

The paper analyzes proteogenomic heterogeneity in ovarian tumors using multiregion sampling and reveals distinct expression patterns between tumor epithelium and stroma.

bioRxiv · Oct 6, 2020 · PreprintCancer Biology

Pseudomonas aeruginosa biofilms display carbohydrate ligands for CD206 and CD209 that interfere with their receptor function

S. Singh, Y. Almuhanna, M. Alshahrani, D. Lowman, P. J. Rice, C. Gell, Z. Ma, B. M. Graves, D. Jackson, K. Lee, R. Kelkar, J. Koranteng, D. Mitchell, A. da Silva, F. Hussain, , L. Martinez-Pomares

This paper identifies CD206 and CD209 as receptors for Pseudomonas aeruginosa biofilm carbohydrates, showing they interfere with receptor function and may modulate immune responses.

bioRxiv · Apr 20, 2020 · PreprintMicrobiology

Aurora B is required for programmed variations of cytokinesis during morphogenesis in the C. elegans embryo

X. Bai, P.-Y. Lee, C.-Y. Chen, J. R. Simmons, B. Nebenfuehr, D. Mitchell, L. R. Klebanow, N. Mattson, C. G. Sorensen Turpin, B.-C. Chen, E. Betzig, J. N. Bembenek

The paper investigates cytokinesis variations during C. elegans embryonic morphogenesis and finds Aurora B kinase is essential for epithelial polarization and tissue formation.

bioRxiv · Aug 27, 2018 · PreprintCell Biology