C. Kumar

Dbf4-Dependent Kinase Finetunes INO80 Function at Chromosome Replication Origins

The paper identifies DDK-mediated phosphorylation of INO80's Arp8 subunit, which stabilizes the complex and regulates nucleosome spacing at replication origins, enhancing replication efficiency and stress response.

A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture

This study identifies a protein complex involving delta-tubulin, epsilon-tubulin, and TEDC1/2 that is essential for centriole architecture and function.

Human complement Factor H and Properdin act as soluble pattern recognition receptors and differentially modulate SARS-CoV-2 Infection

This study shows that complement factors FH and FP interact with SARS-CoV-2 proteins and differentially modulate viral entry and inflammatory responses in A549 cells.

Human Surfactant Protein D Facilitates SARS-CoV-2 Pseudotype Binding and Entry in DC-SIGN Expressing Cells, and Downregulates Spike protein Induced Inflammation

This study shows that rfhSP-D enhances SARS-CoV-2 Spike protein binding to DC-SIGN and increases viral uptake in DC-SIGN-expressing cells while reducing inflammation.

Quantitative crosslinking and mass spectrometry determine binding interfaces and affinities mediating kinetochore stabilization

This study uses quantitative XLMS to determine binding interfaces and affinities in the kinetochore complex, showing phosphorylation reduces KD values by ~200-fold, essential for cell viability.

The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

This study investigates how RNA:DNA hybrid structures and G-quadruplexes influence R-loop-replisome collisions, showing structural differences determine replication outcomes.

A bacterial derived plant- mimicking cytokinin hormone regulates social behaviour in a rice pathogen

This study identifies a bacterial cytokinin hormone produced by Xoo that regulates planktonic lifestyle and virulence in rice pathogens.

Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes and normal tissues

The paper uses proteomics to compare metabolic pathways across tissues in prediabetes, type 2 diabetes, and normal controls, identifying tissue-specific metabolic dysregulation.

Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type-2 diabetes

The paper identifies metabolic defects in type-2 diabetes by analyzing intra- and inter-individual differences in metabolites across multiple tissues.