M. Okumura

The paper investigates how human insulin resistance to degradation by IDE varies with dose and identifies structural features of the insulin hexamer that influence degradation kinetics without zinc.

This study identifies neuromuscular gene expression in thymoma-associated myasthenia gravis by analyzing bulk and single-cell RNA-seq data, linking it to specific thymic epithelial cell subpopulations.

This study compares the efficiency of PDI and ERp46 in catalyzing disulfide bond formation in nascent chains during translation, showing ERp46 is more effective early on.

This study identifies a unique adhesive motif in P5 that enables dimerization, which is essential for its structural stability and functional roles in ER quality control.

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

This study shows that Ran-GTP is not essential for NuMA activation in spindle pole focusing but is required for HURP polarization and spindle length regulation during prometaphase.

This study characterizes GPx7 and GPx8, showing GPx7 efficiently oxidizes PDI via H2O2, while GPx8's role in PDI oxidation is less central.

The paper identifies manumycin polyketides as molecular glues that bind UBR7 and P53, impairing breast cancer pathogenicity through p53 activation and cell death.

This study uses optogenetic reconstitution to show that NuMA clusters Dynein-Dynactin to generate cortical spindle-pulling forces through multi-arm interactions.