Author

T. Shimamura

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 2 Biochemistry· 1 Cancer Biology· 1 Evolutionary Biology· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:statistical model· 4 Organism:plant (other)· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

K. Nakamura· 3 shared T. Fukuda· 3 shared Y. Nishikawa· 3 shared E. Petrunenko· 2 shared E. Pimenova· 2 shared H. Fujita· 2 shared H. Tsuboi· 2 shared J. Koseki· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersEvolutionary Biology

K. Nakamura

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Survivability and Life Support in Sealed Mini-Ecosystems with Simulated Planetary Soils

T. Sato, K. Abe, J. Koseki, M. Seto, J. Yokoyama, T. Akashi, M. Terada, K. Kadowaki, S. Yoshida, Y. A. Yamashiki, T. Shimamura

The paper explores sustainable life-support systems for space by simulating Earth ecosystems, identifying challenges like moisture and temperature, and highlighting microbial roles in ecosystem stability.

Scientific Reports · Nov 1, 2024Peer-reviewedEcology

In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1-mutant lung cancer

J. Deng, D. H. Peng, D. Fenyo, Y. Hao, A. Lopez, D. Levin, M. Meynardie, M. Quinteros, M. Ranieri, S. Sahu, S. Lau, E. Shum, V. Velcheti, S. R. Punekar, N. Rekhtman, , K.-K. Wong

The paper identifies CD38 as a therapeutic target in LKB1-mutant lung cancer through in vivo metabolomics and shows that targeting CD38 inhibits tumor growth.

bioRxiv · Apr 18, 2023 · PreprintCancer Biology

Characterization of various remdesivir-resistant mutations of SARS-CoV-2 by mathematical modeling and molecular dynamics simulation.

S. Torii, K. S. Kim, J. Koseki, R. Suzuki, S. Iwanami, Y. Fujita, Y. D. Jeong, Y. Matsuura, T. Shimamura, S. Iwami, T. Fukuhara

This study identifies remdesivir-resistant SARS-CoV-2 mutations using viral reconstruction, mathematical modeling, and molecular dynamics simulations, showing mutations reduce antiviral activity without increasing viral production.

bioRxiv · Feb 22, 2022 · PreprintMicrobiology

Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota

T. Jaunet-Lahary, T. Shimamura, M. Hayashi, N. Nomura, K. Hirasawa, T. Shimizu, M. Yamashita, K. Kojima, Y. Sudo, T. Tamura, H. Iwanari, T. Hamakubo, S. Iwata, K.-i. Okazaki, T. Hirai, A. Yamashita

This study determines the crystal structures of OxlT, an oxalate transporter, and reveals its mechanism for selective oxalate uptake and exclusion of other carboxylates.

bioRxiv · Nov 15, 2021Biochemistry

Two-way migration of Lychnis wilfordii caused by the circular landform of Japan-Korea-northeast China-Russian Far East region and its suggestion for conservation in northeast Asia

S. Tamura, M. Kwak, G. Kokubugata, C.-h. Park, B.-Y. Lee, T. Fukuda, E. Petrunenko, I. Koksheeva, E. Pimenova, P. Krestov, S. Bondarchuk, J.-S. Ma, H.-C. Zhou, H. Tsuboi, Y. Nishikawa, , K. Nakamura

This study investigates the genetic structure and migration routes of Lychnis wilfordii across northeast Asia, suggesting conservation strategies based on its evolutionary history.

bioRxiv · Feb 6, 2020 · PreprintEvolutionary Biology

Serpentine mountain uplift in northern Japan triggered the divergence of a narrow endemic from a widespread (sub)arctic Asia-Alaska species complex of Lagotis (Plantaginaceae)

A. Sugano, T. Fukuda, Y. Murai, C. Olga, S. Yoshihisa, Y. Tsunamoto, H. Tsuboi, Y. Nishikawa, T. Shimamura, H. Fujita, K. Nakamura

The paper investigates the divergence of two narrow endemic Lagotis species in northern Japan from a widespread (sub)arctic Asia-Alaska species complex, linking it to mountain uplift and ecological factors.

bioRxiv · Nov 28, 2019 · PreprintEcology

Merger of Betula tatewakiana (Betulaceae) from northern Japan to northeast Asian B. ovalifolia based on ploidy level

Y. Shiotani, T. Fukuda, E. Pimenova, E. Petrunenko, P. Krestov, S. Bondarchuk, Y. Nishikawa, T. Shimamura, Y. Fujimura, K. Nakamura

The paper resolves a taxonomic dispute by showing Betula tatewakiana is tetraploid and morphologically identical to B. ovalifolia, leading to their merger.

bioRxiv · Nov 28, 2019Plant Biology