RNA conformational propensities determine cellular activity
M. L. Kelly, R. Roy, A. Geng…·H. M. Al-Hashimi
The paper alters and measures conformational propensities of HIV-1 TAR RNA to predict binding affinities and cellular activity.
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4 papers
Recent·Most cited
M. L. Kelly, R. Roy, A. Geng…·H. M. Al-Hashimi
The paper alters and measures conformational propensities of HIV-1 TAR RNA to predict binding affinities and cellular activity.
C. E. Peters, U. Schulze-Gahmen, M. Eckhardt…·N. J. Krogan
The paper reports the cryo-EM structure of SETD3 interacting with enterovirus protease 2A and shows that mutations in the SET domain reduce binding and protect against infection.
M. Gupta, C. M. Azumaya, M. Moritz…·K. I Pawar
The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.
M. Schuller, G. J. Correy, S. Gahbauer…·Smi
The paper identifies new chemical fragments binding to the SARS-CoV-2 Nsp3 macrodomain through crystallographic screening and computational docking, validating their binding with biophysical techniques.