V. Cmentowski

Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex

The paper investigates how kinetochores facilitate the rapid assembly of the mitotic checkpoint complex (MCC) by co-orienting SAC catalysts in vitro.

Role of PLK1 in the epigenetic maintenance of centromeres

The paper identifies a phosphorylation network regulated by PLK1 that controls a conformational switch necessary for CENP-A deposition, essential for centromere maintenance.

A mechanism that integrates microtubule motors of opposite polarity at the kinetochore corona

The paper identifies CENP-E's role in regulating DD kinetochore loading through the corona scaffold, ensuring coordinated bidirectional transport.

Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin

The paper shows Spindly adopts a closed conformation that blocks Dynein-Dynactin binding, and mutations induce an open state that enables interaction, with kinetochores promoting Spindly activation.

Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores

The paper reports the structure of the RZZ complex and demonstrates the molecular mechanism of corona assembly at human kinetochores using cryo-EM and in vitro assays.