Therapeutic targeting of ACLY in T-ALL in vivo
V. da Silva-Diz, A. Singh, M. Aleksandrova…·D. Herranz
This study identifies ACLY as an overexpressed therapeutic target in T-ALL, showing its antileukemic effects and reciprocal relationship with MYC.
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3 papers
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V. da Silva-Diz, A. Singh, M. Aleksandrova…·D. Herranz
This study identifies ACLY as an overexpressed therapeutic target in T-ALL, showing its antileukemic effects and reciprocal relationship with MYC.
O. Lancho, A. Singh, V. da Silva-Diz…·D. Herranz
This paper identifies a NOTCH1-SIRT1-KAT7 axis in T-ALL that promotes leukemia and resistance to therapy, suggesting new therapeutic targets.
V. da Silva-Diz, B. Cao, O. Lancho…·D. Herranz
This study shows that MB1-47, a mitochondrial uncoupling compound, effectively inhibits T-ALL cell proliferation and extends survival in mouse models without toxicities.