Author

E. Chiles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

X. Su· 4 shared D. Herranz· 2 shared O. Lancho· 2 shared S. Luo· 2 shared V. da Silva-Diz· 2 shared A. Alasadi· 1 shared A. S. Huffmyer· 1 shared A. Singh· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

X. Su

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Coral larvae employ nitrogen sequestration mechanisms to stabilize carbon provisioning from algal symbionts under increased temperature

A. S. Huffmyer, J. Ashey, E. Strand, E. Chiles, X. Su, H. M. Putnam

This study shows coral larvae maintain carbon provisioning from algal symbionts under heat stress by sequestering nitrogen into dipeptides, reducing symbiont growth but preserving photosynthesis and carbon transfer.

bioRxiv · Jun 7, 2024Cell Biology

Linking genotypic and phenotypic changes in the E. coli Long-Term Evolution Experimentusing metabolomics

J. S. Favate, K. S. Skalenko, E. Chiles, X. Su, S. S. Yadavalli, P. Shah

The paper links mutations to metabolic changes and fitness in E. coli from the LTEE using metabolomics and integrates this with mutation and expression data.

bioRxiv · Feb 15, 2023 · PreprintEvolutionary Biology

A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell Leukemia

O. Lancho, A. Singh, V. da Silva-Diz, L. Tottone, P. Renck Nunes, M. Aleksandrova, J. Khatun, S. Luo, C. Zhao, H. Zheng, E. Chiles, Z. Zuo, P. P. Rocha, X. Su, H. Khiabanian, D. Herranz

This paper identifies a NOTCH1-SIRT1-KAT7 axis in T-ALL that promotes leukemia and resistance to therapy, suggesting new therapeutic targets.

bioRxiv · May 21, 2022Cancer Biology

A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia

V. da Silva-Diz, B. Cao, O. Lancho, E. Chiles, A. Alasadi, S. Luo, D. Augeri, S. Minuzzo, S. Indraccolo, X. Su, S. Jin, D. Herranz

This study shows that MB1-47, a mitochondrial uncoupling compound, effectively inhibits T-ALL cell proliferation and extends survival in mouse models without toxicities.

bioRxiv · Jun 23, 2020Cancer Biology