B. Cao

Ligand supplementation restores the cancer therapy efficacy of an antirheumatic drug auranofin from serum inactivation

This study shows that adding thiols to auranofin restores its anticancer activity by modulating albumin-gold binding and enhancing therapeutic efficacy.

Human microbiota is a reservoir of SARS-CoV-2 advantageous mutations

The paper identifies that the human microbiota contributes to SARS-CoV-2 mutations by replicating bacterial mRNAs with advantageous mutations, leading to chimeric RNAs and altered viral properties.

Discovery of microsized RNA-derived RNAs and polypeptides in human cells

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

3D co-culture of macrophages and fibroblasts in a sessile drop chip for unveiling the role of macrophages in skin wound-healing

This study develops a sessile drop chip to create 3D spheroids of fibroblasts and macrophages, showing that M2 macrophages enhance fibroblast proliferation and differentiation in a wound-healing model.

Chi-miR-3880 mediates the regulatory role of interferon gamma in goat mammary gland

This study investigates the IFN{gamma}/chi-miR-3880/DDX58 axis in goat mammary gland lactation, showing its role in regulating proliferation, lipid formation, apoptosis, and involution through specific signaling pathways.

An R-R-type MYB transcription factor promotes nonclimacteric pepper fruit ripening pigmentation

This study identifies a MYB transcription factor that regulates capsanthin biosynthesis in nonclimacteric pepper fruit, showing its role in carotenoid accumulation and interaction with abscisic acid.

Prevalent regulation of GATA2/3 and MSX2 on endogenous retrovirus-derived regulatory elements in human trophoblast stem cells

This study identifies GATA2/3 and MSX2 as key regulators of ERV-derived enhancers in human trophoblast stem cells, revealing their role in placental gene regulation.

Antiviral function and viral antagonism of the rapidly evolving dynein activating adapter NINL

This study identifies NINL as an antiviral innate immune component targeted by viruses through proteolytic cleavage, revealing its role in interferon response and viral antagonism.

Identification and calibration of ultrabright localizations to eliminate quantification error in SMLM

This paper identifies and calibrates ultrabright localizations in SMLM to improve quantification accuracy for biomolecular organization.

Convergence of MCR-8.2 and chromosome-mediated resistance to colistin and tigecycline in an NDM-5-producing ST656 Klebsiella pneumoniae from a lung transplant patient

This study reports a pan-drug-resistant Klebsiella pneumoniae isolate carrying NDM-5 and MCR-8.2 genes, along with chromosomal resistance mechanisms to colistin and tigecycline.

Pharmacological inhibition of the VCP/proteasome axis rescues photoreceptor degeneration in RHOP23H rat retinal explants

The paper shows that inhibiting VCP/proteasome activity rescues photoreceptor degeneration in RHOP23H rat retinal explants.

Improving localization precision via restricting biomolecule confined stochastic motion in SMLM

This study investigates stochastic motion of biomolecules in SMLM and shows that restricting this motion improves localization precision.

Activated Expression of Master Regulator MYB31 and of Capsaicinoid Biosynthesis Genes Results in Capsaicinoid Biosynthesis and Accumulation in the Pericarp of the Extremely Pungent Capsicum chinense

The paper shows that MYB31 activation and CBG expression in the pericarp of C. chinense leads to high capsaicinoid accumulation, explaining the extreme pungency of these peppers.

3D Interferometric Lattice Light-Sheet Imaging

This paper introduces 3D-iLLS, a live-cell imaging technique that improves 4D resolution and signal-to-noise ratio by combining SPIM with 4Pi interferometry.

A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia

This study shows that MB1-47, a mitochondrial uncoupling compound, effectively inhibits T-ALL cell proliferation and extends survival in mouse models without toxicities.

Novel culture method to diagnose fungal infections with biopsy tissues

This paper introduces a novel tissue biopsy culture method that improves fungal detection compared to traditional methods.

Gene Panel Sequencing in a Chinese High-risk Breast Cancer Cohort

The paper analyzes gene panel sequencing data from 829 Chinese high-risk breast cancer patients to identify pathogenic variants and variants of uncertain significance across 115 hereditary cancer susceptibility genes.

Lipid rafts increase to facilitate ectoderm lineage specification of differentiating embryonic stem cells

The paper shows lipid rafts increase during mESC differentiation and support ectoderm lineage specification and pluripotency exit.

Structures of the PKA RIα holoenzyme with the FLHCC driver J-PKAcα or wild type PKAcα

This paper reports the crystal structures of J-PKAc fusion and wild-type PKA holoenzymes, revealing structural differences and conformational dynamics that may impact their function in FLHCC.

SPIN1 promotes tumorigenesis by blocking the uL18-MDM2-p53 pathway

This study identifies SPIN1 as a regulator of the uL18-MDM2-p53 pathway, showing that SPIN1 promotes tumorigenesis by inhibiting p53 activation.