An imputed ancestral reference genome for the Mycobacterium tuberculosis complex better captures structural genomic diversity for reference-based alignment workflows
L. B. Harrison, V. Kapur, M. A. Behr
The paper introduces an imputed ancestral reference genome (MTBC0) for the Mycobacterium tuberculosis complex that improves read mapping and SNP calling compared to existing references.
bioRxiv · Sep 7, 2023 · PreprintMicrobiology