Whole exome precision oncology targeting synthetic lethal vulnerabilities across the tumor transcriptome
J. S. Lee, N. U. Nair, L. M. Chapman, S. Sinha, K. Wang, H. Cha, E. Rubin, R. Berger, V. Lazar, R. Kurzrock, M. R. Gilbert, S. S. Hannenhalli, S.-H. Lee, K. Aldape, E. Ruppin
This paper predicts patient response to cancer therapies using computationally derived genetic interactions across multiple tumor transcriptomics datasets.
bioRxiv · Feb 16, 2020 · PreprintCancer Biology