Author

H. Cha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

S.-H. Lee· 2 shared A. de Castro· 1 shared C. Moore· 1 shared E. Mugarza· 1 shared E. Rubin· 1 shared E. Ruppin· 1 shared J. Boumelha· 1 shared J. Downward· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

S.-H. Lee

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2 papers

Recent·Most cited

CRISPR/Cas9 screen identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer

J. Boumelha, A. de Castro, N. Bah, H. Cha, S. de Carne Trecesson, S. Rana, P. Anastasiou, E. Mugarza, C. Moore, R. Goldstone, P. East, K. Litchfield, S.-H. Lee, M. Molina-Arcas, J. Downward

The paper identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer through CRISPR/Cas9 screening and shows targeting COX-2 enhances immune checkpoint blockade efficacy.

bioRxiv · Apr 13, 2023Cancer Biology

Whole exome precision oncology targeting synthetic lethal vulnerabilities across the tumor transcriptome

J. S. Lee, N. U. Nair, L. M. Chapman, S. Sinha, K. Wang, H. Cha, E. Rubin, R. Berger, V. Lazar, R. Kurzrock, M. R. Gilbert, S. S. Hannenhalli, S.-H. Lee, K. Aldape, E. Ruppin

This paper predicts patient response to cancer therapies using computationally derived genetic interactions across multiple tumor transcriptomics datasets.

bioRxiv · Feb 16, 2020 · PreprintCancer Biology