E. Rubin

Antibiotics damage the colonic mucus barrier in a microbiota-independent manner

This study shows antibiotics damage the colonic mucus barrier independently of microbiota, leading to bacterial penetration and IBD exacerbation.

Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β

This study shows that IL-1β production during Salmonella infection is harmful, reducing neutrophil recruitment and inhibiting Salmonella expansion by altering epithelial cell metabolism and complement system interactions.

Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress

This study shows that autophagy regulates mucus secretion in intestinal goblet cells by reducing ER stress, thereby maintaining intestinal homeostasis.

BORIS/CTCFL-mediated chromatin accessibility alterations promote a pro-invasive transcriptional signature in melanoma cells

This study shows that BORIS/CTCFL alters chromatin accessibility in melanoma cells, promoting a pro-invasive transcriptional signature by upregulating invasion genes and downregulating tumor suppressors.

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

This study maps chemical-genetic interactions in Mycobacterium tuberculosis to identify how carbon metabolism and cell wall structure affect drug efficacy, revealing environment-dependent and -independent interactions.

Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination

This paper analyzes the gray whale transcriptome to identify gene expression patterns associated with longevity, finding high expression of DNA repair and ubiquitination genes.

Whole exome precision oncology targeting synthetic lethal vulnerabilities across the tumor transcriptome

This paper predicts patient response to cancer therapies using computationally derived genetic interactions across multiple tumor transcriptomics datasets.

BORIS/CTCFL promotes a switch from a proliferative towards an invasive phenotype in melanoma cells

This study shows that BORIS promotes a switch from a proliferative to an invasive phenotype in melanoma cells through transcriptional reprogramming.