V. LeBleu

Engineered immunomodulatory extracellular vesicles derived from epithelial cells acquire capacity for positive and negative T cell co-stimulation in cancer and autoimmunity

This study engineers extracellular vesicles from epithelial cells to express immunomodulatory proteins, showing they can induce both positive and negative T cell co-stimulation in cancer and autoimmunity.

Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner

This study shows that MRTX1133, a KrasG12D inhibitor, reduces early pancreatic lesions and, when combined with immunotherapy, regresses advanced PDAC by enhancing CD8+ T cell activity.

Autophagy is associated with survival and resiliency of fibroblasts in long-term decaying post-mortem parenchymal tissue

This study shows fibroblasts survive longer in decaying post-mortem tissue and activate autophagy and lysosomal pathways to maintain viability.

Multiple antibodies identify glypican-1 associated with exosomes from pancreatic cancer cells and serum from patients with pancreatic cancer

The paper confirms Glypican-1 enrichment on pancreatic cancer exosomes using multiple antibodies and demonstrates specific detection in patient serum.