Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drive rapid and potent immunogenicity capable of single-dose protection
K. Konrath, K. Liaw, Y. Wu, X. Zhu, S. Walker, Z. Xu, K. Schultheis, N. Chokkalingam, N. J. Tursi, J. Du, M. Sullivan, M. Purwar, A. Moore, V. Machado, I. Maricic, , D. W. Kulp
This study develops glycan-modified SARS-CoV-2 nanoparticle vaccines that induce potent neutralizing antibodies and single-dose protection against SARS-CoV-2 in multiple animal models.
bioRxiv · Apr 28, 2021Immunology