D. W. Kulp

HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

Involvement of ArlI, ArlJ, and CirA in Archaeal Type-IV Pilin-Mediated Motility Regulation

This study identifies ArlI, ArlJ, and CirA as regulators of pilin-mediated motility in Haloferax volcanii through genetic and expression analyses.

Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drive rapid and potent immunogenicity capable of single-dose protection

This study develops glycan-modified SARS-CoV-2 nanoparticle vaccines that induce potent neutralizing antibodies and single-dose protection against SARS-CoV-2 in multiple animal models.

Intradermal-delivered DNA vaccine provides anamnestic protection in a rhesus macaque SARS-CoV-2 challenge model

This study evaluates an intradermal DNA vaccine against SARS-CoV-2 in rhesus macaques, showing it induces immune responses and provides protection against viral challenge.

SARS-CoV-2 assays to detect functional antibody responses that block ACE2 recognition in vaccinated animals and infected patients

The paper describes a rapid serological assay to detect functional antibodies blocking ACE2 recognition in vaccinated animals and infected patients.

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

This study shows that high serum neutralizing antibody titers from Env protein vaccination protect rhesus macaques from Tier 2 SHIV challenge, with ~1:500 ID50 titers providing over 90% protection.

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

This study shows that slow delivery immunization in rhesus macaques increases HIV-neutralizing antibody titers and germinal center responses by modulating immunodominance.