Author

V. Ruprecht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 2 Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 7 Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Assay:imaging· 3 Assay:bulk RNA-seq· 2 Organism:C. elegans· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

F. Pezzano· 4 shared M. Krieg· 3 shared S. Wieser· 3 shared V. Venturini· 3 shared A. Ganez-Zapater· 2 shared L. Espinar· 2 shared P. Loza-Alvarez· 2 shared R. Ghose· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersCell Biology

F. Pezzano

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects

R. Ghose, F. Pezzano, S. Kourtis, I. Sheraj, S. Das, A. Ganez-Zapater, U. Ghose, L. Espinar, K. Parapatics, V. Venturini, A. C. Muller, V. Ruprecht, S. Sdelci

This study shows that mechanical confinement causes mitochondria to relocate to the nucleus, leading to a nuclear ATP surge that supports DNA repair and cell cycle progression.

bioRxiv · Dec 20, 2023Cell Biology

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells

S. Conti, V. Venturini, A. Canellas-Socias, C. Cortina, J. F. Abenza, C. S.-O. Attolini, E. M. Guerra, C. K. Xu, J. H. Li, L. Rossetti, G. Stassi, P. Roca-Cusachs, A. Diz-Munoz, V. Ruprecht, J. Guck, , X. Trepat

This study identifies mechanical phenotype differences between LGR5+ and LGR5- colorectal cancer cells, linking them to membrane to cortex attachment proteins and metastatic potential.

bioRxiv · Dec 4, 2023Cancer Biology

Adaptation to ARF6-depletion in KRAS-driven PDAC is abolished by targeting TLR2

R. Ghose, S. Das, J. Urgel-Solas, F. Pezzano, D. Datta, U. Ghose, A. Ganez-Zapater, N. Pardo-Lorente, L. Espinar, L. Garcia, C. Cannata, V. Ruprecht, A. Janic, S. Sdelci

This study identifies TLR2 as a target to counteract adaptation to ARF6 depletion in KRAS-driven PDAC, reducing proliferation, migration, and invasion.

bioRxiv · Nov 30, 2023 · PreprintCancer Biology

Measuring age-dependent viscoelastic properties of organelles, cells and organisms via Time-Shared Optical TweezerMicrorheology

F. Catala-Castro, S. Ortiz-Vasquez, C. Martinez-Fernandez, F. Pezzano, C. Garcia-Cabau, M. Fernandez-Campo, N. Sanfeliu-Cerdan, S. Jimenez-Delgado, X. Salvatella, V. Ruprecht, P. A. Frigeri, M. Krieg

This paper introduces a time-shared optical tweezer microrheology method to measure age-dependent viscoelastic properties of biological materials, demonstrating its application in biomolecular condensates, zebrafish cells, and C. elegans.

bioRxiv · Oct 17, 2023 · PreprintBiophysics

Advected percolation in the actomyosin cortex drives amoeboid cell motility

J. M. Garcia-Arcos, J. Ziegler, S. Grigolon, L. Reymond, G. Shajepal, C. J. Cattin, A. Lomakin, D. J. Mueller, V. Ruprecht, S. Wieser, R. Voituriez, M. Piel

The paper identifies advected percolation as a mechanism driving amoeboid cell motility by analyzing actin cortex dynamics in motile blebs.

bioRxiv · Jul 14, 2022 · PreprintBiophysics

Volumetric bioluminescence imaging of cellular dynamics with deep learning based light-field reconstruction

L. F. Morales-Curiel, G. Castro--Olvera, A. Gonzalez, L.-C. Lin, M. El-Quessny, M. Porta-de-la-Riva, J. Severino, L. Battle, D. Ramallo, V. Ruprecht, P. Loza-Alvarez, M. Krieg

This paper improves bioluminescence microscopy with deep learning for low-light imaging, enabling high-resolution volumetric and timelapse imaging of cellular dynamics in living organisms.

bioRxiv · May 31, 2022 · PreprintBioengineering

The nucleus measures shape deformation for cellular proprioception and regulates adaptive morphodynamics

V. Venturini, F. Pezzano, F. Catala Castro, H.-M. Häkkinen, S. Jimenez-Delgado, M. Colomer-Rosell, M. Marro Sanchez, Q. Tolosa-Ramon, S. Paz-Lopez, M. A. Valverde, P. Loza-Alvarez, M. Krieg, S. Wieser, V. Ruprecht

The paper shows the nucleus acts as a shape deformation sensor, enabling cells to adapt behavior to their microenvironment through calcium-dependent mechano-transduction.

bioRxiv · Dec 5, 2019 · PreprintCell Biology

A reconstituted mammalian APC-kinesin complex selectively transports defined packages of axonal mRNAs

S. Baumann, A. Komissarov, M. L. Gili, V. Ruprecht, S. Wieser, S. P. Maurer

This study reconstitutes a mammalian mRNA transport system showing APC, kinesin-2, and KAP3 drive selective axonal mRNA transport via 3UTR guanine-rich sequences.

bioRxiv · Sep 13, 2019Cell Biology